Toxin-Induced Models of Neurological Disorders

Drug-Induced Neurological Disorders

Amygdalar Models of Neurological and Neuropsychiatric Disorders

Toxin-Induced Parkinson’s Disease Models

Page e1 The Topic “Toxin-Induced Parkinson’s Disease Models’ includes articles on experimental neurotoxic chemicals models of Parkinson’s Disease (PD). The model toxicants with differing chemical structures recapitulate PD owning to their action on multiple molecular targets. These reports have provided with deeper understanding on the neurodegenerative events associated with the progressive di...

The potential of induced pluripotent stem cells in models of neurological disorders: implications on future therapy.

There is an urgent need for new and advanced approaches to modeling the pathological mechanisms of complex human neurological disorders. This is underscored by the decline in pharmaceutical research and development efficiency resulting in a relative decrease in new drug launches in the last several decades. Induced pluripotent stem cells represent a new tool to overcome many of the shortcomings...

Stem Cell Therapy in Pediatric Neurological Disorders

Pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. The two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...